MSc thesis project within CFD: Discrete element modelling (DEM) of adhesive ternary mixture
About the company
ÅF Pöyry is an international leader within engineering, design and advisory services. We create solutions to support our customers worldwide to act on sustainability as well as the global trends of urbanisation and digitalisation. We are more than 16,000 devoted experts within the fields of infrastructure, industry and energy operating across the world to create sustainable solutions for the next generation.
About the job
Drug delivery into the respiratory system is predominantly achieved using Dry Powder Inhalation (DPI). A major obstacle in the inhalation process is to maintain the size of particulate drugs at micron scale despite their strong tendency to aggregate. This obstacle is coped with by depositing drugs over larger particles, i.e. carriers, via the adhesive mixing process. Performance of carrier-based DPIs can be significantly enhanced by inclusion of a small amount of fine excipient particles into the binary blend of carrier and drug particles. An unsettled question on the contribution of fine excipient particles in the DPI formulation is the effect of critical attributes including the excipient’s material properties and the amount and the size of added fine particle.
This MSc thesis project aims to understand the effect of size and mass ratio of added fine particles on the mixing performance. This is achieved by Computational Fluid Dynamics (CFD) simulations of ternary systems using the discrete element method (DEM). A series of simulations need to be done, based on experimental design methods, to unravel the effect of these critical parameters on the DPI formulation.
The workflow of this project can be broken down to the following steps: Grasping fundamentals of DPI formulation and the DEM simulation framework through literature review. Designing the required simulations based on the selected variables. Performing simulations and postprocessing the results using EDEM software.
Who are you?
We are looking for students with a profile towards mathematical modeling. Suitable master programs are for example MPISC and Applied Mechanics. Courses in fluid and solid dynamics, CFD, programing and mathematical modeling are meritorious. The work is intended to start in January 2020 and finish after 20 weeks of full time work (before the summer).
This thesis is a collaboration between Chalmers Chemical Engineering, ÅF Technical analysis. The work is based on ongoing research at Chalmers, the student will be situated and supervised at the ÅF office at Grafiska Vägen in Göteborg. The work is connected to pharmaceutical applications and the project will be followed and the results presented to stakeholders in the near region.BackgroundEfficient
Supervisor and contact at ÅF: Ph.D. Per Abrahamsson, firstname.lastname@example.orgAnsök här